28 April 1999

Intriguing compound libraries from new combinatorial chemistry company

ChemOvation has introduced a range of innovative compound libraries to give the strongest possible lead-generating potential, and accelerate drug candidate realisation.

Privileged random libraries are based on the following building blocks: Pyrimidines, triazines, piperazines, guanidines and sulphonamides. Scaffold-based random libraries are built around novel and known structures used in new situations. ChemOvation also designs focused libraries based on hits from random libraries.

The synthesis method is selected to complement the chemistry in each case, and any established reaction can be taken to build novel compounds, which can be ClogP and size restrained if required. Purification method is also chosen to suit, with an appropriate level of HPLC checking. Optional extras include computational toxicity and metabolic screening, plasma protein binding and diversity measurements.

All ChemOvation libraries have high purity levels and are supported by a distinctive physicochemical information package.

Further Information:

Dr Keith Menear

ChemOvation Ltd
Foundry Lane
Horsham
West Sussex, RH13 5PX
United Kingdom

Phone +44 (0)1403 248844
Fax +44 (0)1403 248855
Email:keith.menear@chemovation.com
Website: www.chemovation.com